SHERP

Multiplex Targeting, Tracking, and Imaging of Apoptosis by Fluorescent Surface Enhanced Raman Spectroscopic Dots

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Authors
Yu, Kyeong Nam; Lee, Sang-Myung; Han, Ji Yun; Park, Hyunmi; Woo, Min-Ah; Noh, Mi Suk; Hwang, Soon-Kyung; Kwon, Jung-Taek; Jin, Hua; Kim, Yong-Kweon; Hergenrother, Paul J.; Jeong, Dae Hong; Lee, Yoon-Sik; Cho, Myung-Haing
Issue Date
2007-06-29
Publisher
American Chemical Society
Citation
Bioconjugate Chem. 18(4), 1155-1162
Abstract
We have developed multifunctional fluorescent surface enhanced Raman spectroscopic tagging material (F-SERS dots) composed of silver nanoparticle-embedded silica spheres with fluorescent organic dye and specific Raman labels for multiplex targeting, tracking, and imaging of cellular/molecular events in the living organism. In this study, F-SERS dots fabricated with specific target antibodies (BAX and BAD) were employed for the detection of apoptosis. The F-SERS dots did not show any particular toxicity in several cell lines. The F-SERS dots could monitor the apoptosis effectively and simultaneously through fluorescent images as well as Raman signals in both cells and tissues with high selectivity. Our results clearly demonstrate that F-SERS dots can be easily applicable to multiplex analysis of diverse cellular/molecular events important for maintaining cellular homeostasis.
ISSN
1043-1802
Language
English
URI
http://hdl.handle.net/10371/8338
DOI
https://doi.org/10.1021/bc070011i
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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