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High Dietary Inorganic Phosphate Affects Lung through Altering Protein Translation, Cell Cycle, and Angiogenesis in Developing Mice

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Authors
Jin, Hua; Chang, Seung -Hee; Xu, Cheng-Xiong; Shin, Ji-Young; Chung, Youn-Sun; Park, Sung-Jin; Lee, Yeon-Sook; An, Gil-Hwan; Lee, Kee-Ho; Cho, Myung-Haing
Issue Date
2007-08-13
Publisher
Oxford University Press
Citation
Toxicol. Sci. 100, 215-223
Keywords
Aktprotein translationcell cycleangiogenesislunginorganic phosphate
Abstract
Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Several studies indicate that Pi may affect lung cell development through Na/Pi cotransporter (NPT). Several NPT subtypes have been identified in mammalian lung, and considerable progress has been made in our understanding of their function and regulation. Therefore, current study was performed to elucidate the potential effects of high dietary Pi on lungs of developing mice. Our results clearly demonstrate that high dietary Pi may affect the lung of developing mice through Akt-related cap-dependent protein translation, cell cycle regulation, and angiogenesis. Our results support the hypothesis that Pi works as a critical signal molecule for normal lung growth and suggest that careful restriction of Pi consumption may be important in maintaining a normal development.
ISSN
1096-6080
Language
English
URI
http://hdl.handle.net/10371/8339
DOI
https://doi.org/10.1093/toxsci/kfm202
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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