Publications
Detailed Information
Receptor-mediated gene delivery using chitosan derivatives in vitro and in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, T.-H. | - |
dc.contributor.author | Jiang, H.-L. | - |
dc.contributor.author | Nah, J.-W. | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Akaike, T. | - |
dc.contributor.author | Cho, N.-S. | - |
dc.date.accessioned | 2009-09-01 | - |
dc.date.available | 2009-09-01 | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Macromolecular Symposia, Vol.249-250, pp.137-144 | - |
dc.identifier.issn | 1022-1360 | - |
dc.identifier.other | 33705 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8340 | - |
dc.description.abstract | The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review, we focused on the specific ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo. Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA. | - |
dc.description.sponsorship | This work is supported by
grants from Ministry of Science and Technology in Korea (M10414030002-05N1403-00210). | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Chitosan | - |
dc.subject | Ligand modification | - |
dc.subject | Non-viral vector | - |
dc.subject | Receptor-mediated gene delivery | - |
dc.subject | Transfection efficiency | - |
dc.title | Receptor-mediated gene delivery using chitosan derivatives in vitro and in vivo | - |
dc.type | Conference Paper | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1002/masy.200750323 | - |
dc.citation.journaltitle | Macromolecular Symposia | - |
dc.identifier.scopusid | 2-s2.0-34547173634 | - |
dc.citation.endpage | 144 | - |
dc.citation.startpage | 137 | - |
dc.citation.volume | 249-250 | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.