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Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study

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Authors
Lee, Hyang Yeon; Kwon, Jung-Taek; Koh, Minseob; Cho, Myung-Haing; Park, Seung Bum
Issue Date
2007-09-01
Publisher
Elsevier
Citation
Bioorg. Med. Chem. Lett. 2007, 17, 6335-6339
Keywords
CadaleneGlycosylationProdrugDrug deliveryAnticancer
Abstract
7-Hydroxy-3-methoxycadalene, isolated from Zelkova serrata Makino, was confirmed as a biologically active natural compound. In this study, the efficacy of cadalene as an anticancer agent was tested. In order to address the poor physicochemical properties of cadalene, we designed and synthesized glycosylated cadalene derivatives for improved solubility and efficient drug delivery as a potential prodrug. In vitro cell viability assays confirmed that glycosylated cadalenes were less toxic and more soluble than cadalene. In an in vivo xenograft study in mice, the oral administration of glycosylated cadalenes caused a significant reduction in tumor size.
ISSN
0960-894X
Language
English
URI
http://hdl.handle.net/10371/8342
DOI
https://doi.org/10.1016/j.bmcl.2007.08.071
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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