장내세균성 풍토병 발생기전에 관한 면역학적 연구

Abstract

The Occurrence of infectious disease is not merely due to contact between microbial agents and host but rather a kind of results of complex interaction between microbial agents and resistance mechanisms of the host. To cause infectious disease. infectious agents have to resist and overcome the specific and non specific defense mechanisms of the host. Host resistance is determined by both non specific physiological and morphological factors and specific factors of immunological phenomena. In order to investigate specific and non specific aspects of the immunities to the enteric infections. the increase of agglutinin titers of serum. the enhancement of antibacterial activities of serum and the enhancement of phagocytosis as results of vaccination were followed. Results were obtained as follows. 1. The agglutinin titers of immune sera were naturally highest to the organism used in the preparation of the vaccines. However: a. Agglutinin titers to S. typhi were more or less higher in the anti-Sh. dysenteriae and and anti-Es. coli sera than in control sera. b. Agglutinin titers to Sh, dysenteriae were noticiably higher in the anti-So typhi and anti-Es. coli sera than in control sera. C. Agglutinin titers to Es. coli were significantly higher in anti-So -typhi and anti-Sh, dysenteriae sera than in control sera. 2. The enhancement of antibacterial activities of immune sera were naturally most noticeable to the organism used in the preparation of the vaccines. However: a. The enhancement of antibacterial activities to S. typhi were more noticeable in antiSh. dysenteriae and anti-Es, coli sera than in control sera. b. The enhancement of antibacterial activities to Sh, dysenteriae were more noticeable in anti-Es. coli and anti-So typhi sera than in control sera. c. The enhancement of antibacterial activities to Es. coli were more noticeable in ant i-Sh. dysenteriae sera than in antj-S. typhi sera or control sera up to 60 minutes. Thereafter viable units of Es. coli showed increase in the immune and control sera. 3. The enhancement of phagocytic activities of immune sera were naturally most significant to organism used in the preparation of the vaccine. However: a. The enhancement of phagocytic activities to S. typhi were more noticeable in antiSIl. dysenteriae and anti-Es, coli sera than in control sera. b. The enhancement of phagocytic activities to Sh. dysenteriae were more noticeable in anti-Es. coli and anti-So typhi sera than in control sera. C. The enhancement of phagocytic activities to Es. coli were more noticeable in antiSh, dysenteriae and anti-So typhi sera than in control sera.