백서태존의 실험기형학적 검사법
The Method of Laboratory Investigation of the White Rat

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이광호; 백상호; 장가영; 김병엽
Issue Date
서울대학교 의과대학
Seoul J Med 1973;14(1):43-45
The following scheme of dissection has been found
useful for studying the effects of teratogenic agents
on rat fetuses. In our laboratory dissection is usually
undertaken on the 21st day of pregnancy, one
day prior to the usual time of parturition.
- 44-
I. Measurments
1) Measure the crown-rump distance
2) Measure the trans-umbilical distance
H. General inspection
1) Check for cleft lip and palate
2) Check for exencephaly, anencephaly, or other
head defect.
3) Inspect for ectopia cordis, exomphalos, ventral
herniation or others.
4) Look for cranioschisis or spina bifida
5) Check digite and limb
6) The eyes
7) The tail should be inspected.
m. Examination of Head
Make three cut
1) At eye-level
2) Across the central part
3) Across the ears
VI. Opening of Body Cavities.
On raising the flap of the central abdominal wall
the umbilical vein is stretched and must be cut.
Check for persistant right umbilical vein.
V. Examination of Thorax
Observe any abnormalities of the lungs and pulmonary
vessels. Abnormalities of many of the great
vessels are common where teratogenic agents are
When cardiovascular abnormalities are encountered,
it is usually advisable to stop dissection and compelte
examination by sectioning the material in paraffin.
\I. Examination of Abdomen and Pelvis.
The rat has no gall bladder. Check the diaphragm
for abnormal openings, and for possible abnormalities
of the kidney. Hydro-ureter and hydronephrosis
are easllyrecognlzed.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 14 No.1 (1973)
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