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MyD88 Signaling Is Not Essential for Induction of Antigen-Specific B Cell Responses but Is Indispensable for Protection against Streptococcus pneumoniae Infection following Oral Vaccination with Attenuated Salmonella Expressing PspA Antigen
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sung-Moo | - |
dc.contributor.author | Ko, Hyun-Jeong | - |
dc.contributor.author | Shim, Doo-Hee | - |
dc.contributor.author | Yang, Jin-Young | - |
dc.contributor.author | Park, Yong Ho | - |
dc.contributor.author | III, Roy Curtiss | - |
dc.contributor.author | Kweon, Mi-Na | - |
dc.date.accessioned | 2009-09-03T22:28:53Z | - |
dc.date.available | 2009-09-03T22:28:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | J. Immunol. 181: 6447-6455 | en |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8594 | - |
dc.description.abstract | TLRs directly induce innate host defense responses, but the mechanisms of TLR-mediated adaptive immunity remain subject to debate. In this study, we clarified a role of TLR-mediated innate immunity for induction of adaptive immunity by oral vaccination with a live recombinant attenuated Salmonella enteric serovar Typhimurium vaccine (RASV) strain expressing Streptococcus pneumoniae surface protein A (PspA) Ag. Of note, oral or intranasal vaccination with RASV expressing PspA resulted in identical or even significantly higher levels of PspA-specific IgG and IgA responses in the systemic and mucosal compartments of MyD88–/– mice of either BALB/c or C57BL/6 background when compared with those of wild-type mice. Although PspA-specific CD4+ T cell proliferation in the MyD88–/– mice was minimal, depletion of CD4+ T cells abolished PspA-specific IgG and IgA responses in the MyD88–/– mice of BALB/c background. Of the greatest interest, MyD88–/– mice that possessed high levels of PspA-specific IgG and IgA responses but minimal levels of CD4+ T cell responses died earlier than nonvaccinated and vaccinated wild-type mice following i.v. or intranasal challenge with virulent S. pneumoniae. Taken together, these results suggest that innate immunity activated by MyD88 signals might not be necessary for Ag-specific Ab induction in both systemic and mucosal sites but is critical for protection following oral vaccination with attenuated Salmonella expressing PspA. | en |
dc.description.sponsorship | This work was supported by the governments of the Republic of Korea, Sweden, and
Kuwait; the Bill & Melinda Gates Foundation; National Institutes of Health Grant R01- AI056289; and by a Korea Science and Engineering Foundation (KOSEF) grant funded by the government of Korea (MEST) (Nos. 2007-04213 and R01-2008-000-10649-0). | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.title | MyD88 Signaling Is Not Essential for Induction of Antigen-Specific B Cell Responses but Is Indispensable for Protection against Streptococcus pneumoniae Infection following Oral Vaccination with Attenuated Salmonella Expressing PspA Antigen | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박성무 | - |
dc.contributor.AlternativeAuthor | 고현정 | - |
dc.contributor.AlternativeAuthor | 심두희 | - |
dc.contributor.AlternativeAuthor | 양진영 | - |
dc.contributor.AlternativeAuthor | 박용호 | - |
dc.contributor.AlternativeAuthor | 권미나 | - |
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