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Enhanced cell proliferation and neuroblast differentiation in the rat hippocampal dentate gyrus following myocardial infarction

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Authors
Hwang, In Koo; Yoo, Ki-Yeon; Han, Tae Hee; Lee, Choong Hyun; Choi, Jung Hoon; Yi, Sun Shin; Lee, So Yeong; Ryu, Pan Dong; Yoon, Yeo Sung; Won, Moo-Ho
Issue Date
2008-12-03
Publisher
Elsevier
Citation
Neurosci. Lett. 450 (2009) 275-280
Keywords
Myocardial infarctionSubgranular zoneNeurogenesisKi67DoublecortinRat
Abstract
Basic and clinical studies have revealed that depression is frequently observed following myocardial infarction (MI). We observed changes in neurons in the subgranular zone of the hippocampal dentate gyrus (DG) 14 days after chronic cardiac ischemia. Cresyl violet staining was conducted to examine neurodegeneration. Cresyl violet-positive neurons in the hippocampus in the MI-operated group were similar to those in the sham-operated group, and Fluoro-Jade B-positive cells were not observed in either group. Next, we observed changes in cell proliferation using Ki67 and in the differentiation of neuroblasts using doublecortin (DCX) in the DG. The number of Ki67- and DCX-positive cells in the subgranular zone of the DG in the MI-operated group was significantly increased compared to that in the sham-operated group. In addition, DCX-positive processes were prominent in the MI group. These results suggest that MI may influence cell proliferation and affect neuroblast differentiation in the subgranular zone of the DG.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/8616
DOI
https://doi.org/10.1016/j.neulet.2008.11.057
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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