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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity

DC Field Value Language
dc.contributor.authorKim, Bang Hyun-
dc.contributor.authorWon, Young Suk-
dc.contributor.authorKim, Dae-Yong-
dc.contributor.authorKim, Bora-
dc.contributor.authorKim, Eun-Young-
dc.contributor.authorYoon, Mijung-
dc.contributor.authorOh, Goo Taeg-
dc.date.accessioned2009-09-03T22:55:38Z-
dc.date.available2009-09-03T22:55:38Z-
dc.date.issued2008-
dc.identifier.citationBMB Rep. 42, 91-95en
dc.identifier.issn1976-6696-
dc.identifier.urihttp://hdl.handle.net/10371/8622-
dc.description.abstractPeroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity.
To test this relationship, we divided female wildtype and
PPARα-deficient mice fed on a high fat diet into the following
groups: mock-operated, ovariectomized (OVX), and E2-treated.
The visceral white adipose tissue and plasma cholesterol levels
were increased significantly in wild type OVX and decreased in
the E2-treated group, but interestingly not in PPARα-deficient
mice. The mRNA levels of lipoprotein lipase in adipose tissue
were also increased in only wild type OVX and decreased significantly
in E2-treated mice. These novel results suggest the possibility
of signaling crosstalk between PPARα and E2, causing
obesity in vivo.
en
dc.description.sponsorshipThis work was supported by a grant from the Korean Ministry
of Heath and Welfare (A000385) and a grant from the Seoul R
& BD Program (11117M0214882).
en
dc.language.isoenen
dc.publisher한국생화학분자생물학회 = Korean Society for Biochemistry and Molecular Biologyen
dc.subjectEstrogenen
dc.subjectLPLen
dc.subjectObesityen
dc.subjectPPARαen
dc.subjectSignaling crosstalken
dc.titleSignal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposityen
dc.typeArticleen
dc.contributor.AlternativeAuthor김방현-
dc.contributor.AlternativeAuthor원영석-
dc.contributor.AlternativeAuthor김대용-
dc.contributor.AlternativeAuthor김보라-
dc.contributor.AlternativeAuthor김은영-
dc.contributor.AlternativeAuthor윤미정-
dc.contributor.AlternativeAuthor오구택-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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