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Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bang Hyun | - |
dc.contributor.author | Won, Young Suk | - |
dc.contributor.author | Kim, Dae-Yong | - |
dc.contributor.author | Kim, Bora | - |
dc.contributor.author | Kim, Eun-Young | - |
dc.contributor.author | Yoon, Mijung | - |
dc.contributor.author | Oh, Goo Taeg | - |
dc.date.accessioned | 2009-09-03T22:55:38Z | - |
dc.date.available | 2009-09-03T22:55:38Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | BMB Rep. 42, 91-95 | en |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8622 | - |
dc.description.abstract | Peroxisome proliferator-activated receptor α and estrogen are
believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPARα-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E2-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E2-treated group, but interestingly not in PPARα-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E2-treated mice. These novel results suggest the possibility of signaling crosstalk between PPARα and E2, causing obesity in vivo. | en |
dc.description.sponsorship | This work was supported by a grant from the Korean Ministry
of Heath and Welfare (A000385) and a grant from the Seoul R & BD Program (11117M0214882). | en |
dc.language.iso | en | en |
dc.publisher | 한국생화학분자생물학회 = Korean Society for Biochemistry and Molecular Biology | en |
dc.subject | Estrogen | en |
dc.subject | LPL | en |
dc.subject | Obesity | en |
dc.subject | PPARα | en |
dc.subject | Signaling crosstalk | en |
dc.title | Signal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김방현 | - |
dc.contributor.AlternativeAuthor | 원영석 | - |
dc.contributor.AlternativeAuthor | 김대용 | - |
dc.contributor.AlternativeAuthor | 김보라 | - |
dc.contributor.AlternativeAuthor | 김은영 | - |
dc.contributor.AlternativeAuthor | 윤미정 | - |
dc.contributor.AlternativeAuthor | 오구택 | - |
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