Browse

Non-linear molecular pattern classification using molecular beaconswith multiple targets

Cited 2 time in Web of Science Cited 3 time in Scopus
Authors
Lee, In-Hee; Lee, Seung Hwan; Park, Tai Hyun; Zhang, Byoung-Tak
Issue Date
2013-12
Publisher
Elsevier Ireland Ltd
Citation
Biosystems Vol.111 No.3, pp. 206-213
Keywords
복합학DNA computingMolecular pattern classificationNon-linear classificationMolecular beaconsBiological data analysis
Abstract
In vitro pattern classification has been highlighted as an important future application of DNA computing. Previous work has demonstrated the feasibility of linear classifiers using DNA-based molecular computing. However, complex tasks require non-linear classification capability. Here we design a molecular beacon that can interact with multiple targets and experimentally shows that its fluorescent signals form a complex radial-basis function, enabling it to be used as a building block for non-linear molecular classification in vitro. The proposed method was successfully applied to solving artificial and real-world classification problems: XOR and microRNA expression patterns.
ISSN
0303-2647
Language
English
URI
http://hdl.handle.net/10371/91118
DOI
https://doi.org/10.1016/j.biosystems.2013.05.008
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse