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Genetic and environmental influences on sodium intake determined by using half-day urine samples: the Healthy Twin Study

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Authors
Kho, Minjung; Lee, Jung Eun; Song, Yun-Mi; Lee, Kayoung; Kim, Kyunga; Yang, Sarah; Joung, Hyojee; Sung, Joohon
Issue Date
2013-12
Publisher
American Society for Nutrition
Citation
American Journal of Clinical Nutrition Vol.98 No.6, pp. 1410-1416
Keywords
복합학
Abstract
Background: Salt is essential in our diet, but excess intake is a well-established risk factor for hypertension. The presence and importance of genetic contributions to salt intake, however, are not well understood.Objective: The aim of this study was to examine whether a genetic predisposition and an environmental influence exist for sodium intake and salt habit.Design: In a twin-family cohort, half-day urine samples from 1204 individuals (133 pairs of monozygotic twins, 29 pairs of dizygotic twins, and 880 singletons) were collected to assess 24-h sodium intakes. Daily total sodium intake, sodium density per calorie (Na-D), and salt habit questions were analyzed with adjustment for other epidemiologic characteristics. We calculated heritability (h2) and intraclass correlations to examine the genetic and shared environmental contributions to total sodium intake traits.Results: The average sodium intake was 208.4 +/- 107.0 mmol/d. Men had a higher absolute sodium intake (242.6 +/- 117.4 mmol/d), but Na-D did not differ by sex. Moderate genetic influences existed (h2 = 0.31-0.34) for sodium intake and Na-D. We also found that sharing current residence rather than being a family member explained 22% of the variance in Na-D.Conclusion: Our findings suggest that both genetic predisposition and shared environment contribute to sodium intakes and salt habits alike.
ISSN
0002-9165 (print)
1938-3207 (online)
Language
English
URI
http://hdl.handle.net/10371/91215

http://ajcn.nutrition.org/content/98/6/1410/suppl/DCSupplemental

http://ajcn.nutrition.org/content/98/6/1410.full.pdf+html
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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