Chronic Cellular Reactions to Silicon Neural Probe Implant

Abstract

Chronic use of micromachined silicon neural probes is limited due to the formation of a complex sheath of cells and extracellular proteins that electrically isolates devices from adjacent neurons and neuronal damage. Understanding device-tissue interactions in the brain will provide a basis for developing successful interface strategies for biocompatible microdevices. While the reactive responses to single shank silicon devices inserted into neocortex are well characterized, responses in other regions have not been described. This study was designed to determine if the reactive responses observed in hippocampus and thalamus are similar to those observed in neocortex. This information is necessary to design and implement appropriate intervention strategies to control regional cell and tissue responses. Study of responses in hippocampus and thalamus has important scientific and clinical implications.