Identification of synaptic activities in microelectrode array-based neural networks

Abstract

The Microelectrode Arrays (MEAs) have been used for several decades to investigate neuronal networks in vitro. In most of the studies, the neuronal networks have been studied statistically due to complexity of cultured neuronal networks. However, in order to understand the behaviours of neuronal networks dynamically, the identification of synaptic activities of individual neurons is crucial. In this study, we observed individual synaptic activities by utilizing low density neuronal networks arranged orthogonally on MEA’s.