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GUIDING NEURONS AND FIBROBLAST CELLS USING MICROFIBRICATION ON PHOTOPOLYMER FOR IN-SITU NAVIGATON OF CELLULAR PATTERNING

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Authors
Lee, Jae Kyoo; Baac, Hyoungwon; Song, Sang-Ho; Jang, Eunje; Lee, Sin-Doo; Park, Dongeon; Kim, Sung June
Issue Date
2005-09-06
Citation
The 7th Internatinal Conference on Cellular Engineering (ICCE), Seoul, Korea, September 6-9, 2005
Abstract
Cellular patterning has diverse and
potential applications in scientific research and
engineering. We used laser holographic fabrication
to construct the cellular patterning. By the
interference of two laser beam on the polymer micro
and nanoscale grooves were generated on the
photoresponsive polymer. The growth of rat
hippocampal neurons were controlled with the
microfabricated structure. The directions of neurites
were predominant in the perpendicular direction of
the grooves and the growth rates of the neurites were
also stimulated. Two dimensional cellular patterning
of fibroblast cells was constructed along the
patterned microstructures on the polymer. These
results indicate the feasibility of guiding neurons and
fibroblast cells with laser holography, opening the
possibility for in-situ navigation in living cells.
Language
English
URI
http://hdl.handle.net/10371/9139
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Others_전기·정보공학부
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