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Snail inhibits Notch1 intracellular domain mediated transcriptional activation via competing with MAML1

Cited 4 time in Web of Science Cited 4 time in Scopus
Authors
Kim, Hyeon Seop; Jeong, Heewon; Lim, Seung-Oe; Jung, Guhung
Issue Date
2013-03
Publisher
Elsevier
Citation
Biochemical and Biophysical Research Communications, Vol.433 No.1, pp. 6-10
Keywords
자연과학Notch1SnailMAML1CSLHepatocellular carcinoma
Abstract
Notch1 intracellular domain (NICD) is the transcription factor which controls cell fate and differentiation in embryonic and tumor cells. Snail has a critical role which increases invasion and metastasis of cancer cell as a transcription factor and epigenetic regulator. Recently, we discovered NICD induced Snail degradation by direct binding interaction with Snail. In this experiment, we found that Snail suppressed transcriptional activity of the protein complex formed with NICD and RBPJk in nucleus. Moreover, Snail decreased transcription of NICD target genes via competing with MAML1, co-activator, in NICD complex. In conclusion, Snail inhibited NICD-mediated transcriptional activation of target genes by physical interaction with NICD. (c) 2013 Elsevier Inc. All rights reserved.
ISSN
0006-291X
Language
English
URI
http://hdl.handle.net/10371/91637
DOI
https://doi.org/10.1016/j.bbrc.2013.02.079
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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