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Ruthenium-Catalyzed Redox-Neutral and Single-Step Amide Synthesis from Alcohol and Nitrile with Complete Atom Economy

Cited 95 time in Web of Science Cited 95 time in Scopus
Authors
Kang, Byungjoon; Fu, Zhenqian; Hong, Soon Hyeok
Issue Date
2013-08
Publisher
American Chemical Society
Citation
Journal of the American Chemical Society, Vol.135 No.32, pp. 11704-11707
Keywords
복합학
Abstract
A completely atom-economical and redox-neutral catalytic amide synthesis from an alcohol and a nitrite is realized. The amide C-N bond is efficiently formed between the nitrogen atom of nitrile and the alpha-carbon of alcohol, with the help of an N-heterocyclic carbene-based ruthenium catalyst, without a single by-product. A utility of the reaction was demonstrated by synthesizing C-13 or N-15 isotope-labeled amides without involvement of any separate reduction and oxidation step.
ISSN
0002-7863
Language
English
URI
http://hdl.handle.net/10371/91673
DOI
https://doi.org/10.1021/ja404695t
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Journal Papers (저널논문_화학부)
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