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Subtracted SPECT를 이용한 측두엽 간질의 dystonic posturing에 관한 연구 : Ictal Hyperperfusion of Brain Structures Related to Ictal Dystonic Posturing in Temporal Lobe Seizures

DC Field Value Language
dc.contributor.author정기영-
dc.contributor.author주은연-
dc.contributor.author이은경-
dc.contributor.author태우석-
dc.contributor.author한도훈-
dc.contributor.author서대원-
dc.contributor.author홍승철-
dc.contributor.author홍승봉-
dc.creator정기영-
dc.date.accessioned2014-05-15T04:22:48Z-
dc.date.available2014-05-15T04:22:48Z-
dc.date.issued2003-05-
dc.identifier.citation대한신경과학회지, Vol.21 No.5, pp. 479-486-
dc.identifier.urihttps://hdl.handle.net/10371/91773-
dc.description.abstractAlthough dystonic posturing (DP) during temporal lobe seizures is known to be related to basal ganglia activation, the mechanism of the dystonic posturing has not been investigated in greater details . Methods: Thirty-two patients with mesial temporal lobe epilepsy (TLE) underwent ictal and interictal SPECTs. They were classified into two groups: 1) DP with ictal dystonia during ictal SPECT (N=15) and 2) Non-DP without dystonia (N=17). Ictal-interictal SPECT subtraction was performed as follows: co-registration, intensity normalization, subtraction, thresholding and then an overlay to SPGR MRI. The presence and intensity of ictal hyperperfusion were determined in frontal lobe, basal ganglia, temporal lobe and insular cortex. Results: The incidences of ictal hyperperfusion in DP vs. Non-DP were caudate nucleus [80.0%(12/15 patients) vs. 0% (0/17), p=0.001], putamen [93.3% (14/15) vs. 48.2% (8/17), p=0.005], globus pallidus [53.3% (8/15) vs. 23.5% (4/17), p=0.082], thalamus [80.0% (12/15) vs. 41.2% (7/17), p=0.026], insular cortex [46.7% (7/15) vs.23.5% (4/17), p=0.051], orbitofrontal [46.7% (6/15) vs. 35.3% (7/17), p=0.053], medial frontal [6.7% (1/15) vs. 18.7% (2/17), p=0.621], dorsolateral frontal [13.3% (2/15) vs. 18.7%(2/17), p=0.737] in the hemisphere of epileptic side. In patients who showed ictal hyperperfusion in striatum and thalamus, the average intensity of hyperperfusion in DP vs. Non-DP was caudate nucleus 1.67 vs. 0.0, putamen 2.20 vs. 1.05, globus pallidus 1.2 vs. 0.65, thalamus 2.00 vs. 0.88 in the epileptic hemisphere. Conclusions: Caudate nucleus as well as putamen appeared to be important for producing ictal dystonia during TLE seizures. The greater intensity of ictal hyperperfusion in putamen, caudate nucleus and thalamus seems to be related to ictal dystonia.-
dc.language.isokoen
dc.publisher대한신경과학회en
dc.subject의약학en
dc.subjectIctal dystonia-
dc.subjectSPECT subtraction-
dc.subjectIctal hyperperfusion-
dc.subjectBasal ganglia-
dc.titleSubtracted SPECT를 이용한 측두엽 간질의 dystonic posturing에 관한 연구en
dc.title.alternativeIctal Hyperperfusion of Brain Structures Related to Ictal Dystonic Posturing in Temporal Lobe Seizures-
dc.typeArticle-
dc.contributor.AlternativeAuthorJoo, Eun Yeon-
dc.contributor.AlternativeAuthorLee, Eun Kyung-
dc.contributor.AlternativeAuthorTae, Woo Suk-
dc.contributor.AlternativeAuthorJung, Ki-Young-
dc.contributor.AlternativeAuthorHan, Do Hun-
dc.contributor.AlternativeAuthorSeo, Dae Won-
dc.contributor.AlternativeAuthorHong, Seung Chyul-
dc.contributor.AlternativeAuthorHong, Seung Bong-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2003-01/102/2014017262/5-
dc.description.srndSEQ:5-
dc.description.srndPERF_CD:SNU2003-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2014017262-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A079623-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:0-
dc.description.srndDEPT_NM:의학과-
dc.description.srndSCOPUS_YN:N-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2003-01/102/2014017262/5-
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