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Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials
Cited 17 time in
Web of Science
Cited 18 time in Scopus
- Authors
- Issue Date
- 2010-09
- Publisher
- Elsevier
- Citation
- Clinical Neurophysiology, Vol.121 No.9, pp. 1494-1501
- Keywords
- 공학 ; Topiramate ; Cognitive function ; Event-related potential (ERP) ; Standardised low-resolution ; electromagnetic tomography (sLORETA) ; Source localisation
- Abstract
- Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy.Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA).Results: Neuropsychological tests (n = 18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n = 13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions.Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects.Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.
- ISSN
- 1388-2457
- Language
- English
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