녹이의 CCl4에 의한 백서간손상 및 방사선장해에 미치는 영향에 대하여
Effect of Deer-Horn on CCI4 Induced Liver Injury and X-Irradiated Damage in Rats

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dc.identifier.citationSeoul J Med 1973;14(2):191-205en
dc.description.abstractFollowing experiments were designed for the study of effects of deer-horn extract on CCl, induced liver injury and on X-irradiation damage in albino rats. Male rats of Wistar hybrid , weighting 150±10 g, were divided into 6 groups , consisting of 10 or 12 animals each. Three groups were each used for control, CCl, administration and CCIo giving but pretreatment with deer-horn extract, and another three groups were also used for control , X•rradiation and X-irradiation but pretreated with deerhorn. Animals were sacrificed 18 hours after CCI‘ administration or 24 hours after whole hody X irradiation with the dose of 8ooT. Liver and small intestine were removed immediately for the determination of contents of ATP, nucleic acids and lipids in liver, and lipid conte:>ts in small intestine mucous membrance. Following resnlts were obtained. 1) The ATP contents of CCl, poisoned livers was 13.4±2.9T/g wet tissue, indicating much less value than 32. 5±4. 9T/g of control value, and that of CCI, given group pretreated with deer-horn was 20. 9±1. 8T/g, it was thus shown that the previous administration of deer-horn alleviated the decrease in hepatic ATP level of CCI‘ poisoned animals. 2) No appreciable alteration was observed in the hepatic nucleic acid contents by CCl‘ administration, consequently without deer-horn effect. RNA content in hepatic mitochondria, however, was 7. 3±0. 5 pg/ 100 μg N in CCl. poisoned rats, compared to 9.2± 0.2 pg/100 pg N of control value, and to 9. 5±1. 5 pg/ 100 pg N in CCI, poisoned but deer-horn pretreated group. It was thus shown that the previous administration of deer-horn normalized the mitochondrial RNA content in CCl, poisoned liver. 3) The triglyceride content of CCl. poisoned liver was 15. 4±5. 0 mg/g wet tissue, being much higher than 3. 5±0. 7 mg/g of control value, and that of CCI, given but deer•horn pretreated group was 9. 2±3.8 mg/g, which is intermediate between control ane CCl. given groups. The hepatic cholesterol content of CCl, given group pretreated with deer horn was 7. 5±1. 0 mg/g, indication higher value than control one of 6. 4±1. 2 mg/g, but much lower value than 11. 5±4. 0 mg/g in CCI. given group. The hepatic phospholipid contents of control, CCI‘ given and CCI. given but deer-horn pretreated groups, were 39. 1±3. 3 mg/g wet tissue. 41. 0±3. 6 mg/g and 40±7. 8 mg/g, respectively.en
dc.publisher서울대학교 의과대학en
dc.title녹이의 CCl4에 의한 백서간손상 및 방사선장해에 미치는 영향에 대하여en
dc.title.alternativeEffect of Deer-Horn on CCI4 Induced Liver Injury and X-Irradiated Damage in Ratsen
dc.typeSNU Journalen
dc.contributor.AlternativeAuthorAhn, Hyun Jin-
dc.citation.journaltitle서울 의대 잡지 = 서울 의대 학술지 = Seoul Journal of Medicine-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 14 No.3 (1973)
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