신피막제거가 신성고혈압견의 레닌-안지오텐신-알도스테론계에 미치는 영향
Effects of renal decapsulation on renin-angiotensin-aldosterone system in renal hypertensive dogs

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김명철; 이상돈
Issue Date
서울대학교 의과대학
Seoul J Med 1973;14(4):273-281
In 8 mongrel dogs , renal hypertension was produced
by partial constriction of their renal artery and 3
weeks after the constriction of renal artery, reoperation,
decapsulation of both kidneys were done in
every hypertensive dogs. The changes in blood
pressure and body weight were measured every week
during the course of experiment for 5 weeks, and
also simultaneous blood samples were drawn for
analysis of activities of plasma reninl steroid, aldosterone,
sodium and potassium concentrations.
The results obtained were as follows:
1. The control mean systolic pressure before operation
was 136±22 mmHg. After constriction of renal
artery, it was greatly increased within 3 days and
rised up to 3 weeks continuously when maximum
mean value of 264±12 mmHg was measured. However
, blood pressure in every hypertensive dogs were
gradWllly decreased and return to normal 2 weeks
after renal decapsulation.
2. The control plasma renin activities were aver
aged 132±57 ng%/hr. After renal constriction, the
plasma renin activities rised proportionately with the
rise of blood pressure up to 3 weeks. The maximal
value at 3 weeks after operation was 2. 5 times of
control value. Renin activities were also decreased
to almost normal value within 2 weeks by renal
decapsulation. . .f ‘
3. There are no signifi따['t , ~ variations in total
blood steroid either after renal constriction or renal
decapsulation. Aldosterone levels were however
proportionately increased or decreased according to
the blood renin activities. While , blood Na level
was increased and K levels were decreased during
renal arterial constriction period but their relations
hips were reversed after renal decapsulation.
4. The changes in body weight after constriction
of renal artery were increased from 11.8±0. 8kg in
control to 12. 9±0. 8 kg. Thereafter these mean
values were tend to normal value within 2 weeks
after renal decapsulation. The increase in body
weight is supposed to mean the degree of edema due
to Na retension by aldosterone.
From the above data it can be reconfirmed that
remarkable disordered function in R-A-A system in
the renal hyPertension were same with those in the
typical secondary aldosteronism and functions of
R-A-A system in the renal hypertensive dogs also
tend to return to normal by renal decapsulation.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 14 No.4 (1973)
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