인태아대뇌 연상회부(Brodmann 제18피질분야) 피질의 발육 및 세포구축학적 연구
A Study on Development and Cytoarchitectonics of Cerebral Cortex in Supramarginal Gyrus (Brodmann’s Area 18) in Normal Fetus Brain

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윤원태; 이명복
Issue Date
서울대학교 의과대학
Seoul J Med 1973;14(4):297-311
The authors have made a study of the quantitative
changes in the early development of human brain
with special reference to the growth and the cytoar
chitectonics of cerebral cortex in the parastriate area
(Brodmann’s are' 18) in a sample of 98 korean fetal
brains (51 of male & 47 of female) of which the
age ranged from 5th month to completion of fetal
life. The summary of the findings is as follows:-
1. The average thickness of cerebral cortex in
fetal age 5 months was estimated at O.5mm, and
- 309
its growth pattern showed a rather rapid until the
7th month of fetal age, and thereafter with a reI
atively slower rate, it reached at mean value of
1.42 mm in the age of 10th month. The thickness
of cortex was measured at O.5mm on the average
for the brain with the weight of less than 5Ogm,
and the relation between the thickness of cortex
and the weight of brain showed that the development
of cortex in thickness was rather rapid in growth
rate as the weight of brain increased up to the level
of 101-150gm, and then it developed relatively
slowly as the brain got weight of 351gm and there•
after it developed rather rapidly reaching at the
mean value of 1.36mm in thickness when the hrain
got the weight of more than 401gm,
2. The differentiation of the lamination of cerebral
cortex was found to begin in the later part of 6th
month of fetal age or, in terms of the brain weight
when it reached at 71. 8gm,
3. The ahsolute cell density of cerebral cortex
was found to increase with fetal age until 7th month
at which the density became masimum, and there
after it started to decrease gradually as the fetus
age. As for the relationship between the absolute
cell density and the brain weight, the highest mean
value of density was of brain weighing 101-150gm,
and thereafter it showed a gradual decrease.
4. It seemed that the nerve cells of cerebral cortex
might be increasing in number rapidly until the
7th month of fetal life , and after that the number
of nerve cells would not increase substantially.
5. The sexual difference could be observed neither
in the thickness of cortex nor in the relative and
the absolute cell densities.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 14 No.4 (1973)
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