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Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5

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Authors
Kim, Semi; Lee, Jung Weon
Issue Date
2014-03
Publisher
Korea Genome Organization
Citation
Genomics & informatics, Vol.12 No.1, pp. 12-20
Keywords
자연과학EMTinvasionmembrane proteinTM4SF5TMPRSS4
Abstract
The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generatedand is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor arenow thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity andcell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT isbelieved to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT inclinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions andunderlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networksthat induce the EMT and cancer progression.
ISSN
1598-866X
Language
English
DOI
https://doi.org/10.5808/GI.2014.12.1.12
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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