Burkitt 임파종을 암시케하는 미분화형 악성 임파종

Abstract

Burkitts tumor is a variant of malignant neoplasm of the hematopoietic system and is more specifically designated as malignant lymphoma, undifferentiated, Burkitts type. h 27) In 1958, Burl이W) called attention to a remarkable prevalence, in equatorial Africa, of a round cell tumor that appeared predominantly in children between the ages of three and nine years, with predilection for the jaw in males and the ovaries in females. With subsequent investigations from many subspecialty fields, this type of neoplasm has become more apparent with following somewhat distinctive features; (l) An extremely high incidence in African children(median age of 5 years), so high that the tumors comprised 50 per cent of all malignant tumors in this age group in this area. (2) An apparently limited geographical distribution across the middle of Africa, in• volving principally the Belgian Congo, Uganda, Kenya and British East Africa, with some scattered cases in French West Africa and French Equatorial Africa. 5, 6) This relatively humid tropical climate (rainfall over 20 inches per year) suggested the possibility of a specifie arthropod vector and raised the further possibility that the lymphoma might be caused by a transmissible, possibly viral agent requiring specific temperatures and humidity modalities for the survival of insect vector. 4) (3) An unusual anatomic distribution affecting principally the jaw and abdominal region. (4) The absence of leukemic manifestions in all cases, even in the advanced stages of the disease, giving rise sometimes to the designa tion non• -leukemic lymphoma".