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Segregation analysis of mandibular prognathism in Korean orthognathic surgery patients and their families

Cited 8 time in Web of Science Cited 9 time in Scopus
Authors
Ko, Jeong-Min; Suh, Young Ju; Hong, Jongrak; Paeng, Jun-Young; Baek, Seung-Hak; Kim, Young Ho
Advisor
고정민
Issue Date
2013-11
Publisher
E.H Angle Education and Research Foundation
Citation
Angle Orthodontist, Vol.83, No.6, pp. 1027-1035
Keywords
의약학Segregation analysisMandibular prognathismClass III malocclusionKorean
Abstract
Objective: To investigate the existence of genetic influences on the incidence of mandibular prognathism (MP) in Korean Class Ill patients. Materials and Methods: The probands consisted of 100 Class Ill patients with MP (51 men and 49 women; mean age, 22.1 +/- 5.2 years; SNA, 81.2 degrees +/- 3.2 degrees; SNB, 84.1 degrees +/- 3.9 degrees) who underwent orthognathic surgery. Using three-generation pedigree charts, questionnaires, and clinical examinations, general information and information regarding MP for a total of 3777 relatives of the probands (1911 men and 1866 women) was ascertained. Familial correlations of MP between possible pairs in the pedigree were estimated. Heritability (h(2)) of MP under various models was estimated. Segregation analysis was conducted under the assumption of the nonpolygenic multivariate logistic model and finite polygenic mixed model. One-, two-, and three-susceptibility-type models were evaluated. Results: Among 3777 relatives, 199 (97 men and 102 women) were affected with MP (5.3%). Correlation coefficients of MP incidence in full siblings and in parent-offspring were .2003 and .2036, respectively (all P < .001). The h(2) of MP was estimated as 21.5% after adjusting for sex and founder effects. Two- and three susceptibility-type models showed that the general model fit better than the other models. MP incidence did not have a major gene transmission model and was influenced by numerous minor effect genes and their additive effects. Conclusion: These results suggest that the inherited susceptibility to MP in Korean Class Ill patients might be due to the summation of minor effects from a variety of different genes and/or influence of environmental factors, rather than Mendelian transmission of major genes.
ISSN
0003-3219
Language
English
URI
http://hdl.handle.net/10371/92569
DOI
https://doi.org/10.2319/021313-130.1
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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