수면제 및 정신안정제가 면역형성에 미치는 영향에 관한 실험적 연구

Abstract

Experimental studies were performed to observe the influences of the hypnotics and tranquilizers on the immune response in rabbits. Repeated subcutaneous injections of the hypnotics or tranquilizers for six weeks and immunization with horse serum for the last three weeks were performed on every other day during the whole period of the experiment. The number of pyroninophi1ic cells in the spleen, mesentedc lymphnodes and thymus were counted as an indication of antibody formation. The following results and conclusions were obtained. 1. The injections of the hypnotics and tranquilizers show an incrased number of pyroninophilic cells in the spleens and Iymphnodes. The degree of this increase is highest in the Chlordiazepoxide HCI treated group, and follows Barbital sodium, Chlorpromazine HCI and Secobarbital sodium treated groups in decreasing order. 2. The injections of the hypnotics and tranquilizers with horse serum immunization show remarkable increase of the pyroninophilic cells in the spleens and lymphnodes. This effect is most conspicuous in the Chordiazepoxide HCI and Barbital sodium treated group, less conspicuous in the Chlorpromazine Hel and Secobarbital sodium treated group. 3. It may be concluded that the hypnotics and tranguilizers have stimulative effects on the experi• mental antibody formation and the degree of this stimulative effects is conspicuous in Chlordiazepoxide HCI, Barbital sodium, Chlorpormazine HCI and Secobarbital sodium in decreasing order. 4. The pyroninophilic cells in the thymus are negligible in nllmber in all experimental groups of rabbits.