수면제 및 정신안정제가 면역형성에 미치는 영향에 관한 실험적 연구
Experimental Studies on the Influences of the Hypnotics and the Tranquilizers on the Antibody Formation in Rabbits

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서울대학교 의과대학
Seoul J Med 1972;13(2):91-107
Experimental studies were performed to observe
the influences of the hypnotics and tranquilizers on
the immune response in rabbits. Repeated subcutaneous
injections of the hypnotics or tranquilizers for
six weeks and immunization with horse serum for
the last three weeks were performed on every other
day during the whole period of the experiment. The
number of pyroninophi1ic cells in the spleen, mesentedc
lymphnodes and thymus were counted as an indication of antibody formation.
The following results and conclusions were
1. The injections of the hypnotics and tranquilizers
show an incrased number of pyroninophilic cells in
the spleens and Iymphnodes. The degree of this
increase is highest in the Chlordiazepoxide HCI
treated group, and follows Barbital sodium, Chlorpromazine
HCI and Secobarbital sodium treated
groups in decreasing order.
2. The injections of the hypnotics and tranquilizers
with horse serum immunization show remarkable
increase of the pyroninophilic cells in the spleens
and lymphnodes. This effect is most conspicuous in
the Chordiazepoxide HCI and Barbital sodium treated
group, less conspicuous in the Chlorpromazine Hel
and Secobarbital sodium treated group.
3. It may be concluded that the hypnotics and
tranguilizers have stimulative effects on the experi•
mental antibody formation and the degree of this
stimulative effects is conspicuous in Chlordiazepoxide
HCI, Barbital sodium, Chlorpormazine HCI and
Secobarbital sodium in decreasing order.
4. The pyroninophilic cells in the thymus are
negligible in nllmber in all experimental groups of
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.2 (1972)
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