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하지불안증후군이 중추신경계 질환임을 시사하는 임상적, 신경영상학적, 신경생리학적 증거들에 관하여
Clinical, Neuroimaging and Neurophysiologic Evidences of Restless Legs Syndrome as a Disorder of Central Nervous System

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Authors
정기영
Issue Date
2008
Publisher
대한임상신경생리학회
Citation
대한임상신경생리학회지, Vol.10, No.2, pp. 98-100
Keywords
의약학Restless legs syndromedopamineironA11 neuron
Abstract
Restless legs syndrome (RLS) is a sensorimotor neurological disorder in which the primary symptom is a compelling
urge to move the legs, accompanied by unpleasant and disturbing sensations in the legs. Although pathophysiologic
mechanism of RLS is still unclear, several evidences suggest that RLS is related to dysfunction in central nervous system
involving brain and spinal cord. L-DOPA, as the precursor of dopamine, as well as dopamine agonists, plays an essential
role in the treatment of RLS leading to the assumption of a key role of dopamine function in the pathophysiology of
RLS. Patients with RLS have lower levels of dopamine in the substantia nigra and respond to iron administration. Iron,
as a cofactor in dopamine production, plays a central role in the etiology of RLS. Functional neuroimaging studies using
PET and SPECT support a central striatal D2 receptor abnormality in the pathophysiology of RLS. Functional MRI
suggested a central generator of periodic limb movements during sleep (PLMs) in RLS. However, to date, we have no
direct evidence of pathogenic mechanisms of RLS.
ISSN
1229-6414
Language
Korean
URI
http://hdl.handle.net/10371/92638
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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