Clinical Experience with Topiramate in Korean Patients with Epilepsy

Abstract

Purpose: This study aims to evaluate the clinical experiences, including efficacy and adverse events, of topiramate in Korea during the past 10 years. Method: This was an open-label, retrospective observation with post marketing surveillance data of topiramate. 4535 epilepsy patients were enrolled in this study. The subjects were only included from epileptologists whose data included studies of at least a 16-weeks duration period. The survey contained various issues, such as efficacy (responder rate, seizure-free rate), safety, adverse effects and the quality of life in patients.