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알카로이드계열 한약제의 간독성에 관한 실험적 연구 제1편 간거대세포현상 : Hepatoxicity of Alkaloid Herb-Medicine in Korea Part 1. A Histologic Reappraisal of

DC Field Value Language
dc.contributor.author김용일-
dc.date.accessioned2009-09-14T14:56:53Z-
dc.date.available2009-09-14T14:56:53Z-
dc.date.issued1972-09-
dc.identifier.citationSeoul J Med, Vol.13 No.3, pp. 167-175-
dc.identifier.issn0582-6802-
dc.identifier.urihttps://hdl.handle.net/10371/9268-
dc.description.abstractA histopathologic reappraisal of lasiocarpine(pyrrolizidine
alkaloid)-induced megalocytosis of the
liver on rats was carried out. as an attempt to
compare with similar hepatic cell alterations encountered
frequently among Koreans and to clarify
its biological significance on those phenomena.
Megalocytosis. a characteristic hepatic cell unrest,
was found in groups of lasiocarpine and p-dimethylaminoazobenzene
administration. but much advanced
in animals treated with lasiocarpine and p-dimethylaminoazobenzene
together, being progressive and
constant with prolongation of experimental duration
and regenerative activity of underlying hepatic
tissue.
Megalocytosis produced in rats was cytologically and histoioglcally quite similar or nearly identical
to those seen in 27 cases of liver biopsy materials
with history of taking herb-medicine in 23 Koreans.
It 섭i s 이0 f a따ulth야oIr냥 0때p미i띠nl너i o n that demonstration 이0f
hepatic mega띠loc야ytosis is one of important histologic
criteria to screen hepatotoxicity of herb medicine
in Korea.
-
dc.language.isoko-
dc.publisher서울대학교 의과대학-
dc.title알카로이드계열 한약제의 간독성에 관한 실험적 연구 제1편 간거대세포현상-
dc.title.alternativeHepatoxicity of Alkaloid Herb-Medicine in Korea Part 1. A Histologic Reappraisal of-
dc.typeSNU Journal-
dc.contributor.AlternativeAuthorKim, Yong Il-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
dc.citation.endpage175-
dc.citation.number3-
dc.citation.pages167-175-
dc.citation.startpage167-
dc.citation.volume13-
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