미만성 혈관내 응고항진에 관한 연구
A Study on Disseminated Intravascular Coagulation

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서울대학교 의과대학
Seoul J Med 1972;13(3):185-195
Infusing 150 units of thrombin per animal into the ear vein of rabbits for one hour, coagulatiort
studies-platelet counts, fibrinogen concentration,
prothrombin time and partial thromboplastin time
were performed on the arterial blood from aorta
and the venous blood from inferior vena cava, renal
vein and portal vein at one hour and two hours
respecti vely following infusion.
The same observation was also performed on the
rabbits injected prior to thrombin infusion with a
controlled doses of heparin, persantin, epsilon aminocaproic
acid (EACA), histamine and norepinephrine
The results are summerized as follows:
1. Thrombin infused rabbits exhibited not only
prolongation of prothrom1:Jin time and partial thromboplastin
time, but marked decrease in fibrinogen
concentration and platelets counts particulary in
the venous blood from renal vein and the arterial
blood from aorta.
2. Injection of heprain, EACA and persantin
prior to thrombin infusion inhibited the above
effects of thrombin on coagulation factors.
3. Injection of histamine and norepinephrine inje
ction prior to thrombin infusion aggravated the
effect of thrombin on platelet counts in the thrombin
infused rabbits.
4. Heparin exerted marked influence on the venous
blood from renal vein, persantin on the venous
blood from portal vein and histamine on the venous
blood from inferior vena cava.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.3 (1972)
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