Acute stress가 마우스의 간조직 및 혈청내 RNase와 RNase inhibitor 활성에 미치는 영향
Effect of Acute Stress on the Activities of RNase and RNase inhibitor of Liver and Serum in mice

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최영조; 안형진
Issue Date
서울대학교 의과대학
Seoul J Med 1972;13(3):197-202
Acute stress was induced to the mice by intraperitoneal
injection of celite suspension. The activities
of RNase and RNase inhibitor were examined on the liver and serum with the time intervals of
4, 8, 12, 16 and 20 hours after induction of acute
stress, and adrenal ascorbic acid was also determined
to testify the effectiveness of such a stress inducing
The results obtained are as follows.
1. The activity of hepatic acid RNase was markedly
decreased as much as 41%, as compared to
control value, 8 hours after inducing acute stress.
2. No change was observed in the activity of
hepatic and serum total RNase by acute stress, but
the activity of liver alkaline RNase was decreased
31% 12 hours following acute stress and that of
serum alkaline RNase was decreased 32% 8 hours
after inducing stress. The lowered RNase activities
were gradually increased to normal value 20 hours
after celi te injection. The acute stress was thus
shown to induce a marked decrease in RNase activities
of the liver and serum,
3. The hepatic RNase inhibitor was confirmed to
be bound to alkaline RNase , but not to acid
4. The content of adrenal ascorbic acid was
diminished gradually from the initiation of acute
sress, reaching to minimum level 8 hours after
initiating celite induced stress, followed by gradual
increase to control leve l.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 13 No.3 (1972)
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