Publications

Detailed Information

방사선조사에 따르는 Ribonuclease 활성 및 핵산량변동에 대하여 : Effect of X-irradiation on RNase Activity and Nucleic Acid Contents

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors

최영조

Issue Date
1972-09
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.13 No.3, pp. 203-208
Abstract
were divided into 5 groups, each consisting of 6
rats. Four groups of animals were whole•body Xirradiated
with the respective doses of 400 r, 600 r,
700r, and 800r. Animals were killed with the control
group 24 hours after whole-body X-irradiation
and examined the variation of content of nucleic
acids of splenic tissue, and assayed the alkaline and
acid RNase activities of spleen and serum alkaline
RNase activity.
The following results were obtained.
1. There was no marked change of the activity of
splenic alkaline and acid RNase and of serum alkaline
RNase with the dose of 400 r, comparing to
normal value.
2. The activity of splenic alkaline RNase was
lowered around 30% with the doses of 700 rand
800r , while that of splenic acid RNase was increa一
sed 17% with the 600 r dose , but decreased 20%
and 40% respectively with 700 rand 800 r doses.
3. The serum alkaline RNase activity was incr一
eased 23% with 600 r but decreased 25% and 35%
respectively with 700 rand 800 r doses.
4. No distinct variation of the spleen RNA content
was observed with the low dose of 400 r. But
the RNA content of spleen was decreased slightly
but steadily with increasing doses of irradiation.
The spleen DNA content was decreased 10%, 27%,
and 33%, respectively with the doses of GOO r , 700r
and 800 r. Thus the effect of whole-body X•irradiation
was much more marked on DNA than RNA
in the spleen.
6. The significance of variation of RNase activity
was discussed.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/9272
Files in This Item:
Appears in Collections:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share