Antibiotics가 면역형성에 미치는 영향에 관한 실험적 연구-특히 Pyroninophilia 정시세포소견
Experimental Studies on the Influence of tIle Antibiotics on the Antibody Formation in Rabbits

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서울대학교 의과대학
Seoul J Med 1966;7(1):31-41
The influence of antibiotics with small or large doses
upon the antibody formation in rabbits immunized with horse serum were studied by observation of the
appearance of the pyroninophilic cells in the spleen and
mesenteric lymph nodes.
The following results were obtained.
1) The spleen and Iymphnodes of the rabbits immunized
and injected concurrently with small doses of
antibiotics showed more distinct rise in the number of
the pyroninophilic cells than that of the simply immunized.
Accordingly, it is likely to encourage antibody
Regarding the pyroninophilic cells the transferred
lymphoid cells on this occasion were more predominant
than the classical plasma cells.
2) The spleen and Iymphnodes of the rabbits immunized
and injected concurently with large doses of antibiotics
also showed more remarkable rise in the number
of the pyroninophilic cells compared with the precedent.
It therefore seems to promot by for antibody
formation. The transferred lymphoid cells were also more
pronounced in number on this occasion than in the
classical plasma cells. However, as concerns the classical
plasma cells, the number more increased in large
doses of antibiotics than in small doses.
3) There were no significant differences between
chloramphenicol and terramycin on the influence on
the presence of the pyroninophilic cells.
4) Therefore, it is suggested that the moderate quantity
of antibiotics, namely chloramphenicol or terramycin,
accelerates in the experimental antibody format
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 07 No.1 (1966)
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