Antibiotics가 면역형성에 미치는 영향에 관한 실험적 연구-특히 Pyroninophilia 정시세포소견

Abstract

The influence of antibiotics with small or large doses upon the antibody formation in rabbits immunized with horse serum were studied by observation of the appearance of the pyroninophilic cells in the spleen and mesenteric lymph nodes. The following results were obtained. 1) The spleen and Iymphnodes of the rabbits immunized and injected concurrently with small doses of antibiotics showed more distinct rise in the number of the pyroninophilic cells than that of the simply immunized. Accordingly, it is likely to encourage antibody formation. Regarding the pyroninophilic cells the transferred lymphoid cells on this occasion were more predominant than the classical plasma cells. 2) The spleen and Iymphnodes of the rabbits immunized and injected concurently with large doses of antibiotics also showed more remarkable rise in the number of the pyroninophilic cells compared with the precedent. It therefore seems to promot by for antibody formation. The transferred lymphoid cells were also more pronounced in number on this occasion than in the classical plasma cells. However, as concerns the classical plasma cells, the number more increased in large doses of antibiotics than in small doses. 3) There were no significant differences between chloramphenicol and terramycin on the influence on the presence of the pyroninophilic cells. 4) Therefore, it is suggested that the moderate quantity of antibiotics, namely chloramphenicol or terramycin, accelerates in the experimental antibody format lOn.