동종 및 이종 심조직 반복주사에 의한 실험적 심염에 관한 연구
A Study on Experimental Carditis in Rats, Induced by Repeated Injection of Homologous and Heterologous Heart Tissue with Adjuvant

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신현수; 이재구
Issue Date
서울대학교 의과대학
Seoul J Med 1969;10(4):31-47
It is well known that dead or damaged tissue acts
as an irritant to the individual and induce an inflammatory
lesions, but the mechanism concerning to it
is yet unknown.
A study on experimental carditis in male rats
induced by repeated injections of homologous (rat)
and heterologous (rabbit) heart or liver suspension
with or without Freund’ s complete adjuvant is made
as an attempt to produce immunological inflammatory
lesion of heart and clarify the nature and significicance
of this type of lesion as a morohological viewpoint,
concerning to a certain chronic disorder of
human heart. The results obtained are follows:
1) In the animal group in which homologous heart
tissue suspension with adjuvant injected repeatedly,
marked histopathological changes, namely, chronic
interstitial myocarditis with endocarditis and or epicarditis
are observed in the most cases (90%). The
lesions consist of a moderate to marked infiltration of
lymphocytes, plasma cells , mononuclear cells and
eosinophiles, especially around the bloed vHsels in
interstitium of the myocardium extend to the endocardium
and or epicardium, focal in addition a slight to
moderate degree of degeneration, necrosis and diffuse
edema of muscle fibers are obserbed in areas.
2) Without adjuvant, the group in which homologous
heart suspension only injected repeatedly,
showed mild inflammatory changes in 40% of them.
3) The hearts of two animal groups in which
heterologous heart tissue suspension with adjuvant or
adjuvant only is injected repeatedly, show slight
changes of the similar type , but for lesser degree as
compared with two preceding groups.
4) While the hearts of the animals group which
received liver suspension (instead of heart suspension)
with adjuvant, show no inflammatory changes.
5) In other organ tissues, there observed some
hyperplasia of reticuloendothelial system, which is
considered as the adjuvant effect, and some small
lymphoid cell infiltration especially in the lungs.
spleen, liver and kidneys and only in the brain and
liver, a few non-caseous granulomatous lesions are
noted. otherwise. no other particular changes are
6) The above results obtained by this experimen
tation led the author to the conclusion , which says;
Tissue components of the heart might be rendered
antigenic by some unknown reasons, and participate
directly or indirectly to the pathogenesis and disease
process of some chronic inflammatory cardiac lesions
through immunogical mechanism, i. e. autoimmunity.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 07 No.4 (1966)
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