동종 및 이종 심조직 반복주사에 의한 실험적 심염에 관한 연구

Abstract

It is well known that dead or damaged tissue acts as an irritant to the individual and induce an inflammatory lesions, but the mechanism concerning to it is yet unknown. A study on experimental carditis in male rats induced by repeated injections of homologous (rat) and heterologous (rabbit) heart or liver suspension with or without Freund s complete adjuvant is made as an attempt to produce immunological inflammatory lesion of heart and clarify the nature and significicance of this type of lesion as a morohological viewpoint, concerning to a certain chronic disorder of human heart. The results obtained are follows: 1) In the animal group in which homologous heart tissue suspension with adjuvant injected repeatedly, marked histopathological changes, namely, chronic interstitial myocarditis with endocarditis and or epicarditis are observed in the most cases (90%). The lesions consist of a moderate to marked infiltration of lymphocytes, plasma cells , mononuclear cells and eosinophiles, especially around the bloed vHsels in interstitium of the myocardium extend to the endocardium and or epicardium, focal in addition a slight to moderate degree of degeneration, necrosis and diffuse edema of muscle fibers are obserbed in areas. 2) Without adjuvant, the group in which homologous heart suspension only injected repeatedly, showed mild inflammatory changes in 40% of them. 3) The hearts of two animal groups in which heterologous heart tissue suspension with adjuvant or adjuvant only is injected repeatedly, show slight changes of the similar type , but for lesser degree as compared with two preceding groups. 4) While the hearts of the animals group which received liver suspension (instead of heart suspension) with adjuvant, show no inflammatory changes. 5) In other organ tissues, there observed some hyperplasia of reticuloendothelial system, which is considered as the adjuvant effect, and some small lymphoid cell infiltration especially in the lungs. spleen, liver and kidneys and only in the brain and liver, a few non-caseous granulomatous lesions are noted. otherwise. no other particular changes are noted. 6) The above results obtained by this experimen tation led the author to the conclusion , which says; Tissue components of the heart might be rendered antigenic by some unknown reasons, and participate directly or indirectly to the pathogenesis and disease process of some chronic inflammatory cardiac lesions through immunogical mechanism, i. e. autoimmunity.