실험적 일산화탄소(CO) 중독과 대뇌 GABA 및 Glutamic Acid
Brain GABA and Glutamic Acid Content In Experimental CO Poisoning

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서울대학교 의과대학
Seoul J Med 1969;10(4):77-86
One of the everyday risks, especially in winter
season, to which we Koreans are exposed nowadays
has become the poisoning with crbon
monoxide (CO) which, together with other noxious
substances such as S02,NO, H2S, N02,
formaldehde, etc. , '~manates from most Korean
household heating fuel anthracite CO poisoning
is now threatening hundreds, or more lives
across the country every year(l) in Korea.
CO poisoning has not only to do with the system
of home heating and cooking devices in
Korea but also to do with industry, occupational
sources, motor vrnicle exhaust, tobacco
smoking, etc , all over the world. It must be
necessary to deVf~lop adquate socio-economic
pregramming and policies to prevent the adverse
effects of CO poisoning on our health.
of course. Of more urgent in our opinion is to
understand one very nature of CO poisoning in
its basis by way of long-range scientific research,
rather than impatient search for practical
or immediately applicalble measures against
CO poisoning most policy-makers seek. The
problem of whether or not the CO poisoning
result solely from anoxia , for example, has
not been solved. While biochemical studies
associated with CO poisoning are needed in this
regard, experimental studies so far has been
mostly purely biological, such as those dealing with morbidity and/or mortality as related to
co concentration(2,3), etc. Since many of the
symptoms of CO poisoning are more or less of
central nervous system, and gammaaminobutyric
acid(GABA) appears to be an inhibitory factor
in the brain while the glutamic acid excitatory,
attempts were made to demonstrate
relationship, if any, between the brain content
of these amino acids and experimentally produced
CO poisoning primarilly. Experimental
set-ups were further extended to what have in
some aspects to do with CO poisoning, i e hyperbaric
oxygenation , with and without pre
ceeding CO poisoning, hypoxic state and state
of drug-induced anesthesia.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 07 No.4 (1966)
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