SHERP

간난원세포 증식에 관한 실험적 연구
An Experimental Study on the Proliferation of Hepatic Ovalocytes

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Authors
송계용; 김용일; 이재구
Issue Date
1975-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1975;16(1):1-9
Abstract
Ductular cell proliferation induced by various
chemical carcinogens and its sequences in the
experimental animals are well known, . but the
significance and fate in relation with cholangiocar
cinogenesis through the phase of cholangiofibrosis
remain yet inconclusive. The objective of this paper
is to clarify the relationship between cholangiofibr•
osis and cholangiocarcinoma and the causal role of
the former in the cholangiocarcinogenesis.
Fifty rats were perorally administered with 0.06
% p-DAB contained regular diet daily by 10 months,
and various histologic alterations of intrahepatic
biliary system were investigated by light microscopic
methods.
As a non•specific stage. there were 、". ide range of
ovalocytic proliferation during administration of pDAB
as a possible role of setting the stage to the
carcinoma. With the progression of cholangiofibrosis,
was a stage characterized by spotty but noninfiltrative
proliferation of those cells with atypical epithelial
linings prior to final development of cholangiocar
cinoma, equvalent to the stage of dysplasia or
precancerous phase; so the term cholangiodysplasia
is proposed to indicate dual phase of cholangiofibrosis
as a precancerous step to the cholangiocarcinoma
During the neoplastic phase were numerical regre
ssion of such cholangiodysplastic lesions in accordance
to the multicentric development of carcinomatous
transformation.
Language
Korean
URI
http://hdl.handle.net/10371/9333
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 16 No.1 (1975)
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