S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 16 No.1 (1975)
히스타민이 비임신 가토의 자궁 운동성에 미치는 영향
The Effect of Histamine on the Uterine Motility in the Nonpregnant Adult Rabbits
- 안승운; 김기곤; 이순재
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.16 No.1, pp. 81-85
- The effect of histamine on the uterine motility
was investigated in the nonpregnant adult rabbits
in vitro and in vivo.
Arterial blood pressure and intrauterine pressure, which was l;\enerateq by uterine contraction and transmitted via liquid column in a polyethylene
tubing inserted in the uterine cavity. were recorded
on a physiograph through the pressure transducer
before and during histamine infusion.
The longitudinal tension of the isolated uterine
muscle strip was recorded, too, by way of force
transducer through cotton thread
The uterine motility was represented by the mag•
nitude of impulse which was obtained from the
area beneath pressure or tension curve and the
frequency of the uterine contraction which was
counted by the number of waves on recording paper
in a finite period.
The results obtained were as follows:
1. Arterial blood pressure was dropped by the
infusion of 100 μg/ml histamine solution.
2. The uterine motility was increased by the
administration of histamine in vivo.
3. The motility of the uterine muscle strip was
remarkably increased in 0.5μg/ml histamine solution
and it returned to its original level within several
minutes after returning to Ringer-Tyrode’s solution
containing no histamine.
It was inferred that histamine might stimulate
uterine smooth muscle of nonpregnant adult rabbit
by its direct action.