급성일산화탄소중독이 백서신장에 미치는 영향에 관한 병리조직학적 및 효소조직화학적 연구
Histopathologic and Enzyme Histochemical Stndies on the Effect of Acute Carbon Monoxide Poisoning in Rat Kidney

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송계용; 함의근
Issue Date
서울대학교 의과대학
Seoul J Med 1978;19(4):150-167
Carbon monoxide poisoning has been one of the most
serious medical problems in Korea. The frequent
accidents are mainly due to the nationwide public
uses of anthracite coal briquette as main domestic
and industrial fuel. Recently, some of clinical observation
of acute renal failure in patients of carbon
monoxide poisoning were reported. An experimental
study was performed to observe the effects of acute
carbon monoxide poisoning on the kidney of rats , by
means of histopathologic and enzyme histochemical
methods, attempting to explore the mechanism behind
the process of acute renal failure‘
Experimental animals (Sprague-Dawley rats, 67
female , 210-280gm.) were devided into four groups
by the duration of exposure and the conceutration of
carbon monoxide; control U5 rats, unexposure). 1%
CO expo (30min.) , 0.7% CO expo (12 rats, 60min.)
and 0.4% CO expo (8 rats , 120 min.). Histopathologial
investigation and the enzyme activities of succinic
dehydrogenase (SDH) , NADH diaphorase, lactic Kidneydehydrogenase
CLDH) and alkaline phosphatase
CAlk. P.) in kidney were observed by hematoxylin
eosin staining and appropriate enzyme histochemical
The results obtained were as follows:
1) Histologic section of rat kidney in groups of 30
min and 60 min. acute poisoning with 1% and 0.7%
carbon monoxide revealed moderate to marked congestion
of vasa recta especially in the corticornedullary
junction associated with moderate degree hydropic
degeneration of collecting tubules. Mild to moderate
tubular necrosis and focal regeneration were observed
mainly in the distal part of proximal con、oluted
tubules in the inner cortex. The group of 120 min
0.4% acute poisoning showed a case of mild tubular
necrosis out of 8 animals
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 19 No.4 (1978)
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