급, 만성 일산화탄소중독이 흰쥐의 임신양상에 미치는 영향

Abstract

Carbon monoxide poisoning is the most serious and popular noxious gas poisoning in Korea mostly due to the general public uses the anthracite coal briquettes asmain domestic fuel for heat and cooking The fact hat carbon monoxide can diffuse from maternal blood stream to fetal blood has been Confirmed by many investigators. It is known that in the pregnant women acute carbon monoxide poisoning may cause fetal death or congenital malformations whether mothers survive or not. Also there have been many reports on close relationship between the maternal smoking and low birthweight Autors designed this study to observe the efects of acute and chronic exposures to carbon monoxide on the gestation patterns of the rats. One hundred and two rats were divided into 5 groups one for the cont rol , two for the acute exposure to 0.45% of Co, and two for the chronic exposure to 500ppm 1£ Co The control rats and the exposed rats were laparo tomized at the 20th day of gestation and pregnancy interruption rate, litter size.weight of alive fetus and hemograms were observed. The findings obtained are as follows: 1. Pregnancy interruption rate increased in both acute and chronic exposure groups and the group which had simple acute exposure at the 13th day of gestation to 0.45% Corevealed the highest pregnancy interruption rate 2. There is no difference in litter size between the control and the expoxed groups, but the weight of alive fetus decreased in the exposed groups with stat isticaI significance