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Localized stimulation and recording from neural cells with fluid injectable neuronal microneedles

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Authors
Paik, Seng-Joon; Lee, Ahra; Koo, Kyoin; Park, Sunkil; Jeong, Myungjun; Choi, Hyunmin; Lim, Jung-Min; Oh, Seung Jae; Kim, Sung June; Cho, Dong-il
Issue Date
2005-10
Citation
9th International Conference on Miniaturized Systems for Chemistry and Life Science, pp.1177-1179, Boston, Massachusetts, USA, October 9-13, 2005
Keywords
Kainic acidMicrochannelMicroelectrodeNeuronal microneedle
Abstract
A neuronal microneedle, a single-crystalline silicon microneedle with fluidic
microchannels and microelectrodes, is developed for localized stimulation of and recording
from neural cells. The neuronal microneedle delivers drugs such as excitatory amino acids
at the cellular level as well as electrically records neural signals from neural cells. The
fluidic behavior, the mechanical stability, and the electrode-electrolyte interface impedance
of the fabricated neuronal microneedle were characterized, respectively. Then, the neural
cell responses of a brain of a male Sprague-Dawley rat to a 25μM kainic acid (KA)
stimulus were acutely monitored by using the developed neuronal microneedle.
Language
English
URI
http://hdl.handle.net/10371/9382
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Electrical and Computer Engineering (전기·정보공학부)Others_전기·정보공학부
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