E.Coli; 균내독소(Cr^51Cl3표식)의 임신 「랫트」태반, 태아, 특히 그 당원량에 미치는 영향에 관한 실험적연구

Abstract

Transmission of E. coli endotoxin to the foetus and its effect on the placenta and foetus, especially on glycogen content of the foetalliver, after intraperitoneal injection of Cr51 labelled E. coli endotoxin into the pregnant rats were described. The marked level of radioactivity: of the foetal tissue a few hours after injection of the labelled endotoxin into a pregnant rat is conclusive evidence that a considerable amount of the injected endotoxin has reached the foetus via the placenta and that foetal toxaemia has occu~red. E. coli endotoxin is capable of causing lesions in the placenta associated with vaseular engorgement and changes in the foetus associated with low glycogen content of the liver. It is suggested that the low concentration of glycogen in the foetal liver is the outcome firstly of want of glucose available to transfer from mother to foetus due to maternal toxaemia and secondly of consumption of the glycogen previously accumulated in the foetal liver due to foetal toxaemia