SHERP

동위원소법에 의한 적혈구수명의 결정에 관하여
Mathematical theory of the determination of the life span of red blood cells by isotopic method.

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Authors
장태엽; 김순경; 남기용
Issue Date
1960-06
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1960;1(2):97-103
Abstract
A general discussion on the isotopic determination
of the life span of the red blood cells has been
given. By appropriate assumptions. an attempt has
been made to analyze the isotopic curve i. e. the
total number of isotopic atoms in the circulating
red blood cells vs. time. Making use of Laplace
transform of G(t), the number of isotopic atoms
in the circulating red blood cells at time t , we
have found that I;;" G(t) dt/Co(equation(33)) gives
the mean life span of the red blood cells, where
Co is the total number of the isotopes which are
introduced into the circulating red blood cells.
From this relation, We obtained a new simple me·
thod to determine Hie life span of the red blood
cells. The life span of red blood cells obtained by
this method gives good agreement with the previous
values given by the other people.
While analyzing the tale part of the isotopic
curves, we have known that there is a portion of
Nt5s of glycine which is utilized slowly in the formation
of heme after passing through the other
tIssues.
Assuming the atom% excess versus time curve is
composed of 2 terms. e.g.. normal life span term
and random destruction term, estimation of the
ratio of number of red blood cells of normal life
span to random destruction was made. Equation
(32) gives this relation and in figures 4 and 5 data
cited from other sources and calculated are plotted.
Language
Korean
URI
http://hdl.handle.net/10371/9401
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 01 No.2 (1960)
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