SHERP

말초신경 손상에 의한 신경병증성 통증으로 유발된 쥐 뒷다리근 위축
Hindlimb Muscle Atrophy of Rat Induced by Neuropathic Pain

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Authors
최명애; 최정안; 이경숙; 안경주; 김경화
Issue Date
2008
Publisher
대한기초간호자연과학회 = Korean Society of Biological Nursing Science
Citation
J Korean Biol Nurs Sci, 10(1), 88-95
Keywords
통증신경손상근위축(Neuropathic) PainRats(peripheral) Nerve injuryhindlimb musclesMuscular atrophy
Abstract
Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat.

Methods: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined.

Results: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle.

Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.
ISSN
1229-6155
Language
Korean
URI
http://uci.or.kr/G100:I100-KOI(KISTI1.1003/JNL.JAKO200809861410551)

http://hdl.handle.net/10371/9403
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College of Nursing (간호대학)Dept. of Nursing (간호학과)Journal Papers (저널논문_간호학과)
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