흉곽내 하공적맥을 결찰한 토끼의 혈액과 복수사이의 단백질 교환에 관한 실험

Abstract

Disappearance from plasma and appearance in ascItes of T •1824 in the :nferior vena cava occluded rabbits were studied. 7 rabbits aB control and 11 rabbits as experimental group were studied. Ascites of about 80ml was produced about 10 days after partial occlusion (융 of natural diameter) of the inferior vena cava in the thorax. The following observations were made 1. Disappearance curve from plasma was consisted of two parts. e.g.. rapidly disappεaring and slowly disappearing parts 2. The rapidly disappearing part lasted up to 1.5 hour 274 • 5 4 -Duk Gyung Choi: Exchange of Protein between Plasma and Ascites in the Inferior Vena Cava occluded Rabbitsr after infusion of T-1824. Disappearance rate~in experimental group was significantly greater than ·in normal control group. 3. Per cent of T-1824 remaining in the circulation in control group was 81.9% at 1 hour , 66.5% at 2 hour , after infusion. The value in experimental group was 69.6% at 1 hour and 49.8% at 2 hour. 4. The equilibration time of exchange of T-1824 between plasma and ascites was 6-7 hours. 5. There was a decrease in total plasma protein in experimental group accompanied by a decrease in A/G ratio. This decrease was due to the decrease in plasma albumin. Albumin value was 3.95 gm/dl in normal and 3.09 gm/dl in experimental group. 6. Plasma sodium was decreased in experimental group. In normal rabbits sodium concentration was 160.8 mEq/l and 150.0 mEq/l in ascitic rabbits. 7. Histological change of liver was cirrhotic. 8. Computation was made that about 80 ml of Ascites was accumulated in the inferior vena cava occluded rabbits.