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Altered brain metabolism in vestibular migraine: Comparison of interictal and ictal findings

Cited 54 time in Web of Science Cited 60 time in Scopus
Authors
Shin, Jung H.; Kim, Yu K.; Kim, Hyo-Jung; Kim, Ji-Soo
Issue Date
2014-01
Publisher
SAGE
Citation
Cephalalgia, Vol.34 No.1, pp. 58-67
Keywords
복합학Migrainevertigovestibular migrainePETmetabolism
Abstract
Background Vestibular symptoms/signs frequently coexist with migraine, but the mechanisms of migraine-related vestibular dysfunction remain to be elucidated. This study aimed to determine altered brain metabolism in vestibular migraine.Methods Two patients with vestibular migraine underwent F-18-fluorodeoxy glucose (FDG) positron-emission tomography (PET) during and between attacks of vestibular migraine in addition to detailed neurotological evaluation. We analyzed the regional brain metabolism of the patients in comparison with that of age-matched healthy controls in each patient. We also compared ictal with interictal FDG PET using a subtraction method.Results During the attacks, both patients showed an activation of the bilateral cerebellum and frontal cortices, and deactivation of the bilateral posterior parietal and occipitotemporal areas. One patient also showed hypermetabolism in the dorsal pons and midbrain, right posterior insula, and right temporal cortex while the other patient had an additional activation of the left temporal cortex. Compared with interictal images, ictal PET showed increased metabolism in the bilateral cerebellum, frontal cortices, temporal cortex, posterior insula, and thalami.Conclusion During the attacks of vestibular migraine, the increased metabolism in the temporo-parieto-insular areas and bilateral thalami indicates activation of the vestibulo-thalamo-cortical pathway, and decreased metabolism in the occipital cortex may represent reciprocal inhibition between the visual and vestibular systems.
ISSN
0333-1024
Language
English
URI
http://hdl.handle.net/10371/94222
DOI
https://doi.org/10.1177/0333102413498940
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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