Browse

Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study

Cited 29 time in Web of Science Cited 31 time in Scopus
Authors
Kim, Jong Kuk; Bae, Jong Seok; Kim, Dae-Seong; Kusunoki, Susumu; Kim, Jong Eun; Kim, Ji Soo; Park, Young-Eun; Park, Ki-Jong; Song, Hyun Seok; Kim, Sun Young; Lim, Jeong-Geun; Kim, Nam-Hee; Suh, Bum Chun; Nam, Tai-Seung; Park, Min Su; Choi, Young-Chul; Sohn, Eun Hee; Na, Sang-Jun; Huh, So Young; Kwon, Ohyun; Lee, Su-Yun; Lee, Sung-Hoon; Oh, Sun-Young; Jeong, Seong-Hae; Lee, Tae-Kyeong; Kim, Dong Uk
Issue Date
2014-04
Publisher
Korean Neurological Association
Citation
Journal of clinical neurology, Vol.10 No.2, pp. 94-100
Keywords
복합학Guillain-Barré syndrome
Abstract
Background and Purpose No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barre syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. Methods Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AMP) by a single electrophysiological study. Conclusions Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies.
ISSN
1738-6586
Language
English
URI
http://hdl.handle.net/10371/94227
DOI
https://doi.org/10.3988/jcn.2014.10.2.94
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse