Browse

Association Between Insulin Resistance and Bone Mass in Men

Cited 28 time in Web of Science Cited 33 time in Scopus
Authors
Shin, Doosup; Kim, Soyeun; Kim, Kyae Hyung; Lee, Kiheon; Park, Sang Min
Issue Date
2014-03
Publisher
Endocrine Society
Citation
Journal of Clinical Endocrinology and Metabolism, Vol.99 No.3, pp. 988-995
Keywords
의약학
Abstract
Context: The association between insulin resistance and bone mass is still not clear. Objective: The purpose of this study was to evaluate the association between insulin resistance and bone mass. Design and Setting: This was a cross-sectional survey of the nationally representative population. Participants: A total of 3113 men (aged >= 20 years) from the fourth Korean National Health and Nutrition Examination Survey of 2008-2009 were included. Main Outcome Measures: Bone mineral density (BMD) was measured using dual-energy x-ray absorptiometry. Osteopenia and osteoporosis were defined using the World Health Organization T score criteria. Fasting plasma insulin and glucose levels were measured, and insulin resistance was evaluated using the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index. Results: Age-, height-, and weight-adjusted mean BMD values significantly decreased as quartiles of HOMA-IR and the fasting plasma insulin level increased (P for trends <.001). In multivariable logistic regression analyses, participants who had a higher HOMA-IR or fasting plasma insulin level had a higher odds ratio for osteoporosis/osteopenia. Interestingly, the association between fasting plasma insulin level and whole-body BMD differed by the degree of insulin resistance. In the lowest quartile of HOMA-IR, the fasting insulin level was positively associated with BMD. As insulin resistance increased, however, the fasting insulin level was inversely associated with BMD, and this relationship became more significant as the degree of insulin resistance increased. Conclusions: In a nationally representative sample of Korean men, insulin resistance and the fasting plasma insulin level were inversely associated with bone mass. Further studies are required to confirm this association and reveal the underlying mechanisms.
ISSN
0021-972X
Language
English
URI
http://hdl.handle.net/10371/94236
DOI
https://doi.org/10.1210/jc.2013-3338
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Family Medicine (가정의학전공)Journal Papers (저널논문_가정의학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse