흉곽내 하공적맥을 결찰한 토끼의 심장박출량 및 장기 혈액 유통량

Abstract

The effect of partial occlusion of thoracic vena cava inferior to 융 of its natural diameter on radio-iodinated serum albumin (RISA) dilution curve, Cardiac output, uptake of RISA by various organs, organ blood flow in rabbits were observed. 14 rabbits served as normal control group and rabbits were observed 30 minutes after the partial occlusion (acute group). In 10 rabbits observations were made about 10 days after the partial occlusion when ascites and liver cirrhosis appeared, which was confirmed postmortem (chronic group). The findings were as follows: 1. Time course of RISA dilution curve was shortened in occluded group. The shortening of time constants of RISA dilution curve was prominent in the ch rome group 2. There was an increase in cardiac output in the chronic group and no change in the acute group. Car diac index increased to 2.27 l/m2/min in the chronic group as compared to the control value of 1. 17 11m2 Imin. 3. Liver circulation was directly encroachα1 upon by the partial occlusion of thoracic vena cava inferior. Other regional circulation was far less affected by the partial occlusion than the liver circulation. 4. RISA uptake was greatest in liver in all 3 groups. There was an increased RISA uptake by liver in the chronic group, particularly. 5. Organ blood flow manifested the same behavior as the RISA uptake- There was an increased bl0여 flow in liver after partial occlusion. This increased liver blood flow was prominent in the chronic group where ascites and liver cirrhosis appeared.