S-Space Graduate School of Public Health (보건대학원) Dept. of Public Health (보건학과) Journal Papers (저널논문_보건학과)
Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5
- Lee, Hae-Wan; Min, Soo Kee; Ju, Young-Su; Sung, Joohon; Lim, Man Sup; Yang, Dae Hyun; Lee, Bong Hwa
- Issue Date
- Springer Verlag
- Journal of Gastrointestinal Surgery, Vol.15 No.8, pp. 1336-1343
- Downregulation or loss of HLA class I molecules has been demonstrated in human cancers. The aim of this study was to assess the clinical significance of HLA class I expression in gastric cancer.Gastric cancer tissues from 189 patients were examined for expression of HLA class I heavy chain antigens by immunohistochemical staining with EMR8-5. The expression level of HLA class I of tumor cells is categorized by combining an estimate the percentage of immunoreactive cell with an estimate of the staining intensity. The relationship between HLA class I expression and clinicopathologic parameters, patient survival, and tumor recurrence were analyzed.HLA class I was downregulated in 85 (45.0%) of the gastric carcinomas. Staining revealed 104 (55.0%) tumors with strongly positive expression of HLA class I antigens, 76 (40.2%) tumors with weakly positive expression, and 9 (4.8%) tumors with negative expression. The expression of HLA class I antigen did not correlate with any other clinicopathologic parameters. Moreover, HLA class I expression was neither a risk factor for tumor recurrence nor survival.The downregulation of HLA class I expression is not associated with patient prognosis.
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